Foundation / Corporation
Simons Foundation - Simons Foundation Autism Research Initiative (SFARI)
09/07/21 5:00 PM EST
Grants to USA, Canada, and International nonprofit organizations, institutions, government agencies, and investigators affiliated with an IHE, medical school, or research facility for autism research using rats. Funding is intended to bring together a consortium of investigators who will share information and advance autism research.
The mission of the Simons Foundation Autism Research Initiative (SFARI) is to improve the understanding, diagnosis, and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance.
Grants awarded through this RFA are intended to capitalize on the rat as a model system to advance an understanding of the behavioral and circuit neuroscience mechanisms driving autism. This RFA will support a consortium of investigators to collaboratively use SFARI autism rat models to examine the biological basis of complex behaviors and the underlying neural circuits relevant for autism.
SFARI has supported the development of rats carrying mutations to high-confidence autism-related genes on the Long-Evans outbred genetic background (Charles River Laboratories). The genes include FMR1, ARID1B, CHD8, CNTNAP2, DYRK1A, NRXN1, SCN2A and GRIN2B. These same rat models are currently being evaluated through a comprehensive behavioral phenotyping pipeline established by the Simons Initiative for the Developing Brain (SIDB). Access to these models, as well their resulting data from the SIDB pipeline, are available to any qualified researcher.
SFARI encourages proposals that are informed by molecular and cellular insights gleaned from other experimental model systems, such as the mouse, to examine the resulting impact on rat complex behaviors and circuit function. Proposals may include specific experiments to address whether reported cellular mechanisms/phenotypes in other model systems are conserved in the rat, in order to facilitate interpretation of observed phenotypes at the systems and behavioral levels. However, the majority of the grant application should focus on the analysis of behavior and/or systems-level circuit dynamics in SFARI rat models.
SFARI will facilitate coordination across funded projects through a research consortium. While the details are yet to be determined, these will include periodic meetings among funded investigators to discuss challenges and share research findings. SFARI hopes that these serve as organic collaborative opportunities, which could lead to parallel and overlapping approaches across several labs. Costs associated with attending any SFARI-initiated meetings will be covered separately by the Simons Foundation.
SIDB will also regularly update and provide consortium members full access to data obtained from their behavior phenotyping pipeline on the SFARI rat models. Pending availability, there may also be future opportunities for short sabbaticals at SIDB for research trainees/specialists to gain research experience/conduct explorative behavioral experiments with the autism rat resources and expertise available at the University of Edinburgh.
For use of funds information, see Grant Policies and Procedures in Pre-Application Information, below.
GrantWatch ID#: 197433
Each lab may request a maximum of $300,000, inclusive of 20 percent indirect costs, for each year of funding over a period of two (2) to three (3) years.
Two to three years.
Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.
For assistance, please call 800-875-2562 or email firstname.lastname@example.org.
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