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Autism Rat Models Consortium Grant

Grants to USA, Canada, and International Nonprofits, Institutions,
Agencies, and Investigators for Autism Research Using Rats

Agency Type:

Foundation / Corporation

Funding Source:

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Simons Foundation - Simons Foundation Autism Research Initiative (SFARI)

Conf. Date:

07/26/21

Deadline Date:

09/07/21 5:00 PM EST

Description:

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Grants to USA, Canada, and International nonprofit organizations, institutions, government agencies, and investigators affiliated with an IHE, medical school, or research facility for autism research using rats. Funding is intended to bring together a consortium of investigators who will share information and advance autism research.

The mission of the Simons Foundation Autism Research Initiative (SFARI) is to improve the understanding, diagnosis, and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance.

Grants awarded through this RFA are intended to capitalize on the rat as a model system to advance an understanding of the behavioral and circuit neuroscience mechanisms driving autism. This RFA will support a consortium of investigators to collaboratively use SFARI autism rat models to examine the biological basis of complex behaviors and the underlying neural circuits relevant for autism. 

SFARI has supported the development of rats carrying mutations to high-confidence autism-related genes on the Long-Evans outbred genetic background (Charles River Laboratories). The genes include FMR1, ARID1B, CHD8, CNTNAP2, DYRK1A, NRXN1, SCN2A and GRIN2B. These same rat models are currently being evaluated through a comprehensive behavioral phenotyping pipeline established by the Simons Initiative for the Developing Brain (SIDB). Access to these models, as well their resulting data from the SIDB pipeline, are available to any qualified researcher.

SFARI encourages proposals that are informed by molecular and cellular insights gleaned from other experimental model systems, such as the mouse, to examine the resulting impact on rat complex behaviors and circuit function. Proposals may include specific experiments to address whether reported cellular mechanisms/phenotypes in other model systems are conserved in the rat, in order to facilitate interpretation of observed phenotypes at the systems and behavioral levels. However, the majority of the grant application should focus on the analysis of behavior and/or systems-level circuit dynamics in SFARI rat models.

SFARI will facilitate coordination across funded projects through a research consortium. While the details are yet to be determined, these will include periodic meetings among funded investigators to discuss challenges and share research findings. SFARI hopes that these serve as organic collaborative opportunities, which could lead to parallel and overlapping approaches across several labs. Costs associated with attending any SFARI-initiated meetings will be covered separately by the Simons Foundation.

SIDB will also regularly update and provide consortium members full access to data obtained from their behavior phenotyping pipeline on the SFARI rat models. Pending availability, there may also be future opportunities for short sabbaticals at SIDB for research trainees/specialists to gain research experience/conduct explorative behavioral experiments with the autism rat resources and expertise available at the University of Edinburgh. 

For use of funds information, see Grant Policies and Procedures in Pre-Application Information, below. 

GrantWatch ID#:

GrantWatch ID#: 197433

Estimated Size of Grant:

Each lab may request a maximum of $300,000, inclusive of 20 percent indirect costs, for each year of funding over a period of two (2) to three (3) years.

Term of Contract:

Two to three years.

Additional Eligibility Criteria:

Applications from individual labs as well as collaboratives applications of up to three (3) principal investigators are welcomed.

- All applicants and key collaborators must hold a Ph.D., M.D. or equivalent degree and have a faculty position or the equivalent at a college, university, medical school or other research facility.
- SFARI recognizes the importance of diverse viewpoints for scientific advancement. As such, SFARI encourages the inclusion of researchers who span career stages and groups historically underrepresented in science.
- Applications may be submitted by domestic and foreign nonprofit organizations; public and private institutions, such as colleges, universities, hospitals, laboratories and units of state and local government; and eligible agencies of the federal government. There are no citizenship or country requirements.

For additional eligibility information, see FAQs tab on URL for Full Text (RFP).

The Simons Foundation provides equal opportunities to all applicants for funding without regard to race, religion, color, age, sex, pregnancy, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status or any other protected category under federal, state and local law. The foundation also funds programs directed at supporting scientists from disadvantaged backgrounds or underrepresented groups, often working closely with professional societies and other funding agencies.

Postdoctoral associates may not apply as PIs even if your institution is willing to submit an application on your behalf.

BTI awardees may not apply to be PIs on a SFARI application within two years of the BTI grant start date. However, BTI awardees may be named in other personnel roles, including co-investigator and consultant. After the two-year moratorium, BTI awardees may apply as a PI for any SFARI grant program. Note that this moratorium applies only to SFARI grants and no other grant award programs within the Simons Foundation, such as the Simons Collaboration on the Global Brain or the Klingenstein-Simons Fellowship Awards.

Indirect costs are not allowable on equipment; however, indirect costs on small equipment with a unit cost of $10,000 or less is permissible.

Pre-proposal Conference:

To answer questions about this RFA, SFARI will hold an informational Zoom meeting on July 26, 2021 at 11 am EDT.

Interested applicants can register here: https://www.sfari.org/event/sfari-autism-rat-models-consortium-rfa-informational-session/

Pre-Application Information:

The submission deadline is Tuesday, September 7, 2021, 5:00 p.m. Eastern Time.

Important Dates:
Application Available: July 6, 2021
Informational Zoom Meeting: July 26, 2021
Application Deadline: September 7, 2021
Notification to Present to SFARI: December 15, 2021
Team Presentations: January 2022
Award Notification: February 2022

Grant Policies and Procedures: https://www.sfari.org/funding-opportunities/policies-and-procedures/

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Application: https://www.sfari.org/grant/2021-autism-rat-models-consortium-rfa/

For assistance, please call 800-875-2562 or email pcsupport@altum.com.

Scientific inquiries:
sciencerfa@simonsfoundation.org
646-654-0066

Administrative inquiries:
sfarigrants@simonsfoundation.org
646-654-0066

Simons collections inquiries:
collections@sfari.org
646-654-0066

SFARI
Communications Department
Simons Foundation
160 Fifth Avenue, 7th Floor
New York, NY 10010
T: 646.654.0066
F: 646.654.0220

URL for Full Text (RFP):

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Israel

International country outside of the USA, Israel and Canada.

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