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Prevention Pipeline

Grants to USA, Canada, and International Researchers and Clinicians
for Studies Related to the Prevention of Alzheimer's and Dementia

Agency Type:

Foundation / Corporation

Funding Source:

Add to My Calendar 

Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:

10/09/20

Deadline Date:

11/06/20 5:00 PM EST Receipt

Description:

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Grants to USA, Canada, and International clinicians and researchers working at universities, academic medical centers, nonprofits, and biotechnology companies for research on the prevention and treatment of Alzheimer's and related dementias. Applicants must submit a Letter of Intent prior to submitting a full application. Funding is intended to support prevention clinical trials, comparative effectiveness research, and epidemiological studies that explore whether the use of drugs affects the risk for dementia or cognitive decline.

Specifically, the Prevention Beyond the Pipeline RFP supports:

  1. Studies Leveraging the Consortium of Cohorts for Alzheimer's Prevention Action (CAPA): Epidemiological studies contribute unmatched information on whether the risk of dementia or cognitive decline may be influenced by long-term exposure to specific foods or supplements. However, high-powered studies are needed, ideally with dose, duration, and responder profiles, in order to translate epidemiological research into actionable interventions for testing. Through the CAPA Consortium, the ADDF funds collaborative analyses on dementia prevention using a minimum of five longitudinal cohorts, either harmonized or analyzed through parallel analysis of cohorts using a shared analysis script. More information here: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/capa-consortium
  2. Comparative Effectiveness Research: For many health conditions, physicians have a choice of clinically equivalent drugs. Some of these drugs are being investigated for repurposing to treat Alzheimer's or related dementias, due to potential disease-modifying properties that go beyond the treatment of their approved disease indication. The ADDF will consider funding research to generate an evidence base on whether choices in the routine clinical care of pre-existing conditions could protect from dementia. Priority will be given to the comparison of drugs that are otherwise clinically equivalent for the pre-existing condition. Methods may include randomized trials or epidemiology.
  3. Studies of Cognitive Decline and Cognitive Reserve: Cognitive decline through aging and health conditions has been linked to an increased risk of dementia. The ADDF will consider funding programs to prevent and treat these conditions, including cognitive aging, menopause-related cognitive symptoms, postoperative delirium and postoperative cognitive decline, mild and/or repetitive traumatic brain injury, and chemotherapy-induced decline. Methods may include epidemiology or clinical trials. For clinical trial proposals, please see below detailed instructions and priorities under “Funding Priorities for Clinical Trial Proposals” and “Evaluation of Clinical Trial Proposals”.

Current target areas of interest include:

  • Epigenetics
  • Inflammation
  • Mitochondria & metabolic function
  • Neuroprotection
  • Proteostasis
  • Synaptic activity and neurotransmitters
  • Vascular function
  • Other aging targets (e.g. senescent cells)
  • Other novel targets or pathways that are supported by compelling evidence demonstrating a rational biological connection to age-related cognitive decline or dementia risk

Funding Priorities for Clinical Trial Proposals

For clinical trial applications, the ADDF prioritizes novel drug candidates with composition of matter intellectual property (IP) and repurposed and repositioned drugs with strategies to develop novel IP. Applications should include compelling preclinical packages with robust target engagement and efficacy data in relevant animal model(s) and demonstrate blood-brain barrier permeability for CNS targeted therapies.

For clinical trials, the Foundation prioritizes applications that:

  • Include data on dose optimization for the intended route of administration and treatment duration for the drug candidate
  • Provide strong rationale for the proposed clinical population based on the drug candidate’s mode of action
  • Outline strategies for successful recruitment, retention and protocol adherence, with evidence of prior success for recruitment of the proposed number and population
  • Carefully select biomarkers that will measure target engagement and intermediate readouts that are proximal to clinical outcomes 
  • Demonstrate evidence of safety from earlier clinical studies, where available, and plans to address remaining safety concerns in the proposed clinical design
  • For repurposing studies, a supplier that will provide sufficient quantities of the drug or compound to complete the study aims has been identified

GrantWatch ID#:

GrantWatch ID#: 182777

Estimated Size of Grant:

Average Award
- $50,000-$100,000 for epidemiological analyses
- Up to $3,000,000 for clinical trials based on stage and scope of research

Term of Contract:

Average Duration:
Multi-year
Potential for follow-on funding

Additional Eligibility Criteria:

Eligibility:
Funding is open to researchers and clinicians worldwide at:
- Academic medical centers and universities or nonprofits.
- Biotechnology companies. Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

Pre-Application Information:

It is highly recommended that applicants access the ADDF Funding Portal to begin the application process well in advance of any deadlines. Please note, new applicants should allow 1-2 business days for registration.

Upcoming Deadlines
Must be received by 5:00 pm ET on the deadline date.

- Letter of Intent: January 17, 2020
- Invited Full Proposal: February 7, 2020

- Letter of Intent: April 10, 2020
- Invited Full Proposal: May 8, 2020

- Letter of Intent: July 10, 2020
- Invited Full Proposal: August 7, 2020

- Letter of Intent: October 9, 2020
- Invited Full Proposal: November 6, 2020

Applicants may only submit one LOI per cycle and one invited full proposal per cycle, but a single academic institution may have multiple applicants apply for funding for different projects within a cycle. Biotechnology companies are limited to the submission of one LOI and one invited full proposal per cycle.

- For studies requiring additional support, co-funding from other funding agencies or investors is encouraged

All clinical trials receiving ADDF funding must register and submit results for “applicable clinical trials” on the ClinicalTrials.gov Protocol Registration and Results System Information website: https://register.clinicaltrials.gov/

The ADDF considers its application process an iterative one and would be happy to talk to you about your drug development program.

- Application Instructions: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions
- Application and Funding Policies: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies
- Additional information about full proposal stage: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-body-instructions

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply Online: https://addf.fluxx.io/user_sessions/new

For program-related inquiries, please contact:
Yuko Hara, PhD, Acting Director, Aging & Alzheimer's Prevention
yhara@alzdiscovery.org

For application submission inquiries, please contact:
Grants and Mission-Related Investments Team
grants@alzdiscovery.org

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019
212.901.8000
info@alzdiscovery.org

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

Israel

International country outside of the USA, Israel and Canada.

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