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Neuroimaging and CSF Biomarker Development Program

Grants to USA, Canada, and International Researchers for
Research Related to Dementia and Alzheimer's Disease

Agency Type:

Foundation / Corporation

Funding Source:

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Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:

10/09/20

Deadline Date:

11/06/20 5:00 PM ET Receipt

Description:

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Grants to USA, Canada, and International clinicians and researchers for dementia and Alzheimer's disease research. A Letter of Intent must be submitted prior to applying. Funding is intended to advance the development of drugs for dementia and Alzheimer's disease and biomarker tools that aid in this process. This grant program supports the advancement of neuroimaging and CSF biomarkers.

This RFP prioritizes biomarker programs that define a specific use and have potential for commercial and clinical translation, with an emphasis on clinical trials. The RFP supports advancement of neuroimaging and CSF biomarkers that can do one or more of the following:

  • Demonstrate target engagement for novel therapeutics
  • Detect signs of disease earlier and monitor progression
  • More accurately diagnose and distinguish between dementia subtypes

For more information on funding priorities, see "Funding Priorities" on URL for Full Text below.

Specifically, this RFP focuses on:

  • Developing novel PET ligands for clinical use
  • Supporting novel CSF biomarkers
  • Validating established MRI approaches in larger cohorts

Novel biomarkers of neuroinflammation and synaptic integrity are considered high priority. Other target areas of interest include:

  • Neuronal loss
  • Vascular injury and blood-brain barrier integrity
  • Mitochondria and metabolic function
  • Protein misfolding/proteostasis
  • Oxidative stress
  • White matter changes
  • Other novel targets supported by compelling biological rationale and connection to disease

The ADDF has limited interest in CSF measures of amyloid and tau.

Modality Specific Priorities:

  • Neuroimaging:
    • Positron emission tomography (PET)
    • Magnetic resonance imaging (MRI)
    • Magnetic resonance spectroscopy (MRS)
  • Cerebrospinal fluid (CSF) biomarkers
  • Functional activity measures
  • Other novel approaches

For more information on Modality Specific Priorities, see "Modality Specific Priorities" on URL for Full Text below.

GrantWatch ID#:

GrantWatch ID#: 181960

Estimated Size of Grant:

The average award is up to $600,000 based on stage and scope of research.

Term of Contract:

- One year with potential for follow-on funding.
- Multi-year proposals can be considered.

Additional Eligibility Criteria:

Funding is open to researchers and clinicians worldwide at:
- Academic medical centers and universities or nonprofits. Industry partnerships are encouraged.
- Biotechnology companies. Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

ADDF funding is not provided for indirect costs/overhead, capital equipment, equipment service contracts, publication costs, or travel (unless travel is pre-approved under special circumstances).

Peripheral biofluids and digital approaches are supported through the Diagnostics Accelerator RFP.

Pre-Application Information:

Due to the COVID-19 pandemic, ADDF understands there may be delays in submitting applications. It will consider an extension if delays are anticipated. Please email your scientific point person listed at the end of the RFP.

Letters of Intent and Full Proposals must be received by 5:00 PM ET on the deadline date.
Upcoming Deadlines:
- Letter of Intent: January 17, 2020
- Invited Full Proposal: February 7, 2020

- Letter of Intent: April 10, 2020
- Invited Full Proposal: May 8, 2020

- Letter of Intent: July 10, 2020
- Invited Full Proposal: August 7, 2020

- Letter of Intent: October 9, 2020
- Invited Full Proposal: November 6, 2020

- For application instructions, see: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions.
- For Funding Policies, see: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

ADDF Funding Portal: https://addf.fluxx.io/user_sessions/new

The ADDF considers its application process an iterative one and would be happy to talk to you about your drug development program.

For program-related inquiries, please contact:
Meriel Owen, PhD, Scientific Program Officer, Scientific Affairs
mowen@alzdiscovery.org

For application submission inquiries, please contact:
Grants and Mission-Related Investments Team
grants@alzdiscovery.org

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019
info@alzdiscovery.org
212.901.8000

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

Israel

International country outside of the USA, Israel and Canada.

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