Find Nonprofit and Small Business Grants

Advance Search

Only Available for Paid Subscribers
Clear Filters
Search Filters

Program to Accelerate Clinical Trials (PACT)

Grants to USA, Canada, and International
Researchers for Studies on Alzheimer's Therapies

Agency Type:

Foundation / Corporation

Funding Source:

Add to My Calendar 

Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:

10/09/20

Deadline Date:

11/06/20 5:00 PM EST

Description:

Request a Grant Writer

Grants to USA, Canada, and International clinicians and researchers based at nonprofit organizations, universities, medical centers, and companies for research on Alzheimer’s disease and related dementias. Applicants must submit an LOI prior to submitting a full application.

The goal of this RFP is to increase the number of innovative pharmacologic interventions tested in clinical studies for Alzheimer's disease and related dementias. This includes novel, repurposed, and repositioned drugs as well as natural products.

Specifically, the PACT RFP supports:

  1. Early-stage human clinical trials:
    • Phase 1 single ascending dose and multiple ascending dose studies
    • Biomarker-based proof-of-concept or proof-of-mechanism studies. These studies can validate novel molecular targets in humans and de-risk novel therapeutic approaches earlier in clinical development by assessing the potential efficacy of therapeutic interventions using pharmacodynamic outcomes
  2. Regulatory studies:
    • Non-GLP and GLP pharmacology and toxicology studies, pre-formulation, and GMP manufacture required for investigational new drug (IND) and clinical trial authorization (CTA) preclinical packages. Funding is available for preparation of traditional and exploratory IND applications.
    • Long-term toxicology studies to enable longer-term dosing in phase 2 trials
    • GMP manufacture and testing of clinical grade drug required to move into phase 2 or phase 3 trials

The ADDF is interested in small molecules and biologics (e.g. antibodies, peptides, gene therapies).

Current target areas of interest and funding priorities can be found on the URL for Full Text.

GrantWatch ID#:

GrantWatch ID#: 172502

Estimated Size of Grant:

Average Award: Grants are up to $3,000,000 based on stage and scope of research. For studies requiring additional support, co-funding from other funding agencies or investors is encouraged. Payment structure will be negotiated and based on milestone achievements and recruitment.

Term of Contract:

Average duration: Multi-year with potential for follow-on funding.

Additional Eligibility Criteria:

Funding is open to researchers and clinicians worldwide at:

- Academic medical centers and universities or nonprofits. Industry partnerships are strongly encouraged.
- Biotechnology companies. Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

This RFP does not support anti-amyloid approaches (e.g., anti-amyloid aggregation, beta-amyloid vaccines, beta- or gamma-secretase inhibitors) and cholinesterase inhibitors.

Pre-Application Information:

Materials must be received by 5:00 PM EST on the deadline date. Due to the COVID-19 pandemic, ADDF understands that there may be delays in submitting applications. It will consider an extension if delays are anticipated. Please email your scientific point person

Deadlines:

- Letter of Intent: January 17, 2020
- Invited Full Proposal: February 7, 2020

- Letter of Intent: April 10, 2020
- Invited Full Proposal: May 8, 2020

- Letter of Intent: July 10, 2020
- Invited Full Proposal: August 7, 2020

- Letter of Intent: October 9, 2020
- Invited Full Proposal: November 6, 2020

Applications are reviewed in a two-step process:
1. Letters of Intent (LOI): ADDF’s science team will evaluate LOIs to determine whether the proposed project is consistent with the ADDF's mission and funding priorities. LOI decisions will be sent within three weeks of submission.

2. Invited full proposal: Invited full proposals are reviewed by members of the external scientific and business review boards. The 150+ scientific and business reviewers represent some of the world’s most recognized experts from academia, biotech, and pharma. Proposals deemed fundable by reviewers will then undergo further due diligence by ADDF’s science team and advisors to arrive at a final funding decision.

Application & Funding Policies:
https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies

Application Instructions
https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply Online:
https://addf.fluxx.io/user_sessions/new

For program-related inquiries, please contact:

Alessio Travaglia, PhD, Scientific Program Officer
atravaglia@alzdiscovery.org

For application submission inquiries, please contact:

Grants and Mission-Related Investments Team
212.901.8019
grants@alzdiscovery.org

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019

212.901.8000

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

Israel

International country outside of the USA, Israel and Canada.

Suggested Grants:

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735

Fundraising and Publicity Opportunity for USA, Canada, and International Nonprofits for Cult...

Deadline Ongoing

Fundraising opportunity for USA, Canada, and International nonprofit organizations to host a jazz concert held in honor of their organization or cause. Applicants must contact the funding source prior to applying. In addition to funds raised through concert ticket sales

GrantWatch ID#: 123735